Enhanced detection of paramagnetic fluorine-19 magnetic resonance imaging agents using zero echo time sequence and compressed sensing.

ABSTRACT: Fluorine-19 (¹⁹ F) magnetic resonance imaging (MRI) is an emerging technique offering specific detection of labeled cells in vivo. Lengthy acquisition times and modest signal-to-noise ratio (SNR) makes three-dimensional spin-density-weighted ¹⁹ F imaging challenging. Recent advances in tracer paramagnetic metallo-perfluorocarbon (MPFC) nanoemulsion probes have shown multifold SNR improvements due to an accelerated ¹⁹ F T₁ relaxation rate and a commensurate gain in imaging speed and averages. However, ¹⁹ F T₂ -reduction and increased linewidth limit the amount of metal additive in MPFC probes, thus constraining the ultimate SNR. To overcome these barriers, we describe a compressed sampling (CS) scheme, implemented using a "ze

SUBMITTER: Chen J 

PROVIDER: S-EPMC10655826 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature