Characterizing positive and negative valence systems function in adolescent depression: An RDoC-informed approach integrating multiple neural measures.

ABSTRACT: Depression is a prevalent, debilitating, and costly disorder that often manifests in adolescence. There is an urgent need to understand core pathophysiological processes for depression to inform more targeted intervention efforts. The Research Domain Criteria (RDoC) Positive Valence Systems (PVS) and Negative Valence Systems (NVS) have both been implicated in depression symptomatology and vulnerability; however, the nature of NVS alterations is unclear across studies, and associations between single neural measures and symptoms are often small in magnitude and inconsistent. The present study advances characterization of depression in adolescence via an innovative data-driven approach to identifying subgroups of PVS and NVS function by integrating multiple neural measures (assessed by elect

SUBMITTER: Hill KE 

PROVIDER: S-EPMC10655891 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature