Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation.

ABSTRACT: Although we have shown that steroid receptor coactivator-2 (SRC-2), a member of the p160/SRC family of transcriptional coregulators, is essential for decidualization of both human and murine endometrial stromal cells, SRC-2's role in the earlier stages of the implantation process have not been adequately addressed. Using a conditional SRC-2 knockout mouse (SRC-2^d/d ) in timed natural pregnancy studies, we show that endometrial SRC-2 is required for embryo attachment and adherence to the luminal epithelium. Implantation failure is associated with the persistent expression of Mucin 1 and E-cadherin on the apical surface and basolateral adherens junctions of the SRC-2^d/d luminal epithelium, respectively. These findings indicate that the SRC-2^d/d luminal epithe

SUBMITTER: Maurya VK 

PROVIDER: S-EPMC10655894 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature