Urinary cortisol and cardiovascular events in women vs. men: The multi-ethnic study of atherosclerosis.

ABSTRACT: Research suggests that women experience greater cardiovascular ischemic effects from stress than men. Visceral adiposity is an endocrine tissue that differs by sex and interacts with stress hormones. We hypothesized that urinary cortisol would be associated with increased cardiovascular events and change in coronary artery calcium score (CAC) in women, and these relationships would vary by central obesity. In the Multi-Ethnic Study of Atherosclerosis Stress Ancillary study, cortisol was quantified by 12-h overnight urine collection. Central obesity was estimated by waist-hip ratio (WHR). Multivariable Cox models estimated the relationship between cortisol and cardiovascular events and assessed for moderation by WHR. The relationship between cortisol and change in CAC Agatston score was ass

SUBMITTER: Flynn S 

PROVIDER: S-EPMC10655947 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature