Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction.

ABSTRACT:

Background

National guidelines recommend that systolic blood pressure (SBP) in patients with heart failure with reduced ejection fraction (HFrEF) and hypertension be maintained below 130 mm Hg.

Objectives

This study sought to determine associations of SBP <130 mm Hg with outcomes in patients with HFrEF.

Methods

Of the 25,345 patients in the Medicare-linked OPTIMIZE-HF registry, 10,535 had an ejection fraction (EF) ≤40%. Of these, 5,615 had stable SBP (≤20 mm Hg admission to discharge variation), and 3,805 (68%) had a discharge SBP <130 mm Hg. Propensity scores for SBP <130 mm Hg, estimated for each of the 5,615 patients, were used to assemble a matched cohort of 1,189 pairs of patients with SBP <130 versus ≥130 mm Hg, balanced on 58 baseline characteristics (mean age

SUBMITTER: Arundel C 

PROVIDER: S-EPMC10656059 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature