AFRbase: a database of protein mutations responsible for antifungal resistance.

ABSTRACT:

Motivation

Fungal pathogens are known to cause life threatening invasive infections with rising global mortality rates. Besides, the indiscriminate use of antifungals in both clinics and agriculture has promoted antifungal drug resistance in the last decade. Fungi can show drug resistance by a variety of mechanisms. But primary driver in all these hitherto documented mechanisms is stable and heritable point mutations in the key proteins. Therefore, cataloguing mutations that can confer resistance is the first step toward understanding the mechanisms leading to the emergence of antifungal resistance.

Results

In the present, work we have described a database of all the mutations responsible for antifungal resistance. Named as antifungal resistance database (AFRbase), it is bet

SUBMITTER: Jain A 

PROVIDER: S-EPMC10656092 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature