Methodological improvements to meta-analysis of low dose rate studies and derivation of dose and dose-rate effectiveness factors.

ABSTRACT: Epidemiological studies of cancer rates associated with external and internal exposure to ionizing radiation have been subject to extensive reviews by various scientific bodies. It has long been assumed that radiation-induced cancer risks at low doses or low-dose rates are lower (per unit dose) than those at higher doses and dose rates. Based on a mixture of experimental and epidemiologic evidence the International Commission on Radiological Protection recommended the use of a dose and dose-rate effectiveness factor for purposes of radiological protection to reduce solid cancer risks obtained from moderate-to-high acute dose studies (e.g. those derived from the Japanese atomic bomb survivors) when applied to low dose or low-dose rate exposures. In the last few years there have been a numbe

SUBMITTER: Little MP 

PROVIDER: S-EPMC10656154 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature