Concomitant use of magnesium oxide significantly decreases absorption of levodopa preparations in patients with Parkinson's disease.

ABSTRACT:

Introduction

Constipation is one of the most frequent non-motor symptoms of Parkinson's disease (PD), and magnesium oxide (MgO) is a frequently used laxative. This study aimed to investigate the effect of concomitant use of MgO on the pharmacokinetics of levodopa preparations in patients with PD.

Methods

We prospectively enrolled 35 patients with PD and compared the pharmacokinetics of levodopa and carbidopa and motor symptoms with and without MgO. The impact of alterations in pH and the addition of MgO on the solubility of levodopa formulations were also evaluated under in vitro conditions.

Results

Concomitant use of MgO significantly reduced the maximum plasma concentration of levodopa (Cmax) (from 7.66 ± 3.74 μmol/L to 5.82 ± 3.69 μmol/L; p = 0.006) and area

SUBMITTER: Miyaue N 

PROVIDER: S-EPMC10656210 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature