Host genetics and gut microbiota jointly regulate blood biochemical indicators in chickens.

ABSTRACT: Blood biochemical indicators play a crucial role in assessing an individual's overall health status and metabolic function. In this study, we measured five blood biochemical indicators, including total cholesterol (CHOL), low-density lipoprotein cholesterol (LDL-CH), triglycerides (TG), high-density lipoprotein cholesterol (HDL-CH), and blood glucose (BG), as well as 19 growth traits of 206 male chickens. By integrating host whole-genome information and 16S rRNA sequencing of the duodenum, jejunum, ileum, cecum, and feces microbiota, we assessed the contributions of host genetics and gut microbiota to blood biochemical indicators and their interrelationships. Our results demonstrated significant negative phenotypic and genetic correlations (r =  - 0.20 ~  - 0.67) between CHOL and LDL-CH wi

SUBMITTER: Jiang X 

PROVIDER: S-EPMC10656342 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature