Oocyte cryopreservation with in vitro maturation for fertility preservation in girls at risk for ovarian insufficiency.

ABSTRACT:

Purpose

To assess the feasibility and outcomes of oocyte cryopreservation with in vitro maturation (IVM) in post-pubertal girls undergoing fertility preservation (FP) for primary ovarian insufficiency (POI) risk.

Methods

Ovarian stimulation was performed with an antagonist protocol or progesterone priming. Ultrasound monitoring was performed transabdominally. Oocytes were retrieved transvaginally under IV sedation. Immature oocytes were subjected to IVM for up to 36 h. All MII oocytes were vitrified. The main outcome measure was the total number of mature oocytes cryopreserved. The secondary outcome was the increase in the mature oocyte yield after IVM.

Results

Indications for FP included mosaic Turner syndrome (mTS; n = 10), malignancy (n = 3), and POI risk (n = 2).

SUBMITTER: Gayete-Lafuente S 

PROVIDER: S-EPMC10656385 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature