Ontology highlight
ABSTRACT:
SUBMITTER: Kurz J
PROVIDER: S-EPMC10656427 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Kurz Jennifer J Weiss Anna-Carina AC Lüdtke Timo H-W TH Deuper Lena L Trowe Mark-Oliver MO Thiesler Hauke H Hildebrandt Herbert H Heineke Joerg J Duncan Stephen A SA Kispert Andreas A
Development (Cambridge, England) 20220729 15
Smooth muscle cells (SMCs) are a crucial component of the mesenchymal wall of the ureter, as they account for the efficient removal of the urine from the renal pelvis to the bladder by means of their contractile activity. Here, we show that the zinc-finger transcription factor gene Gata6 is expressed in mesenchymal precursors of ureteric SMCs under the control of BMP4 signaling. Mice with a conditional loss of Gata6 in these precursors exhibit a delayed onset and reduced level of SMC differentia ...[more]