Development of a facile method to compute collagen network pathological anisotropy using AFM imaging.

ABSTRACT: Type I collagen, a fundamental extracellular matrix (ECM) component, is pivotal in maintaining tissue integrity and strength. It is also the most prevalent fibrous biopolymer within the ECM, ubiquitous in mammalian organisms. This structural protein provides essential mechanical stability and resilience to various tissues, including tendons, ligaments, skin, bone, and dentin. Collagen has been structurally investigated for several decades, and variation to its ultrastructure by histology has been associated with several pathological conditions. The current study addresses a critical challenge in the field of collagen research by providing a novel method for studying collagen fibril morphology at the nanoscale. It offers a computational approach to quantifying collagen properties, enabling

SUBMITTER: Khattignavong E 

PROVIDER: S-EPMC10656449 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature