Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids.

ABSTRACT: Non-natural amino acids are increasingly used as building blocks in the development of peptide-based drugs as they expand the available chemical space to tailor function, half-life and other key properties. However, while the chemical space of modified amino acids (mAAs) such as residues containing post-translational modifications (PTMs) is potentially vast, experimental methods for measuring the developability properties of mAA-containing peptides are expensive and time consuming. To facilitate developability programs through computational methods, we present CamSol-PTM, a method that enables the fast and reliable sequence-based prediction of the intrinsic solubility of mAA-containing peptides in aqueous solution at room temperature. From a computational screening of 50,000 mAA-containing

SUBMITTER: Oeller M 

PROVIDER: S-EPMC10656490 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature