Uric acid as a mediator in the correlation between white blood cells and preeclampsia severity: a retrospective cohort study.

ABSTRACT: This study aimed to analyze the independent risk factors for predicting preeclampsia severity and explore its underlying mechanism. Clinical data of patients with preeclampsia were collected from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Univariate and multivariate analyses were employed to assess the significant factors associated with preeclampsia severity. Additionally, we performed multivariate logistic regression analysis and mediation analysis to investigate the potential regulatory path. Based on inclusion and exclusion criteria, 731 participants were enrolled: severe preeclampsia (n = 381) and mild to moderate preeclampsia (n = 350). Age, white blood cells (WBC), platelet, creatinine, albumin, uric acid, aspartate aminotransferase, alanine aminotransferas

SUBMITTER: Li BJ 

PROVIDER: S-EPMC10656492 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature