Cigarette smoking and disproportionate changes of thoracic skeletal muscles in low-dose chest computed tomography.

ABSTRACT: Association between smoking intensity and the quantity and quality of thoracic skeletal muscles (TSMs) remains unexplored. Skeletal muscle index (SMI; skeletal muscle area/height²) and percentage of normal attenuation muscle area (NAMA%) were measured to represent the quantity and quality of the skeletal muscles, respectively, and quantification was performed in pectoralis muscle at aortic arch (AA-PM), TSM at carina (C-TSM), erector spinae muscle at T12 (T12-ESM), and skeletal muscle at L1 (L1-SM). Among the 258 men (median age, 62 years [IQR: 58-69]), 183 were current smokers (median smoking intensity, 40 pack-years [IQR: 30-46]). SMI and NAMA% of AA-PM significantly decreased with pack-year (β =  - 0.028 and - 0.076; P < 0.001 and P = 0.021, respectively). Smoking intensity w

SUBMITTER: Lim WH 

PROVIDER: S-EPMC10656498 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature