The man, the plant, and the insect: shooting host specificity determinants in Serratia marcescens pangenome.

ABSTRACT:

Introduction

Serratia marcescens is most commonly known as an opportunistic pathogen causing nosocomial infections. It, however, was shown to infect a wide range of hosts apart from vertebrates such as insects or plants as well, being either pathogenic or growth-promoting for the latter. Despite being extensively studied in terms of virulence mechanisms during human infections, there has been little evidence of which factors determine S. marcescens host specificity. On that account, we analyzed S. marcescens pangenome to reveal possible specificity factors.

Methods

We selected 73 high-quality genome assemblies of complete level and reconstructed the respective pangenome and reference phylogeny based on core genes alignment. To find an optimal pipeline, w

SUBMITTER: Shikov AE 

PROVIDER: S-EPMC10656689 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature