Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in Primary Sjogren's syndrome.

ABSTRACT:

Background

Primary Sjögren's syndrome (pSS) is a progressive inflammatory autoimmune disease. Immune cell infiltration into glandular lobules and ducts and glandular destruction are the pathophysiological hallmarks of pSS. Macrophages are one of the most important cells involved in the induction and regulation of an inflammatory microenvironment. Although studies have reported that an abnormal tissue microenvironment alters the metabolic reprogramming and polarisation status of macrophages, the mechanisms driving macrophage infiltration and polarisation in pSS remain unclear.

Methods

Immune cell subsets were characterised using the single-cell RNA sequencing (scRNA-seq) data of peripheral blood mononuclear cells (PBMCs) from patients with pSS (n = 5) and healthy individuals

SUBMITTER: Zong Y 

PROVIDER: S-EPMC10656691 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature