The iron chaperone poly(rC)-binding protein 1 regulates iron efflux through intestinal ferroportin in mice.

ABSTRACT: Iron is an essential nutrient required by all cells but used primarily for red blood cell production. Because humans have no effective mechanism for ridding the body of excess iron, the absorption of dietary iron must be precisely regulated. The critical site of regulation is the transfer of iron from the absorptive enterocyte to the portal circulation via the sole iron efflux transporter, ferroportin. Here, we report that poly(rC)-binding protein 1 (PCBP1), the major cytosolic iron chaperone, is necessary for the regulation of iron flux through ferroportin in the intestine of mice. Mice lacking PCBP1 in the intestinal epithelium exhibit low levels of enterocyte iron, poor retention of dietary iron in enterocyte ferritin, and excess efflux of iron through ferroportin. Excess iron efflux oc

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10656723 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature