Brazilian green propolis prevent Alzheimer's disease-like cognitive impairment induced by amyloid beta in mice.

ABSTRACT:

Background

The increasing incidence of cognitive impairment has become a health problem in the aging society. Owing to its antioxidant and anti-inflammatory properties, Brazilian green propolis-derived from Baccharis dracunculifolia-is anticipated to possess anticognitive properties. However, the preventive effect of Brazilian green propolis on cognitive impairment remains unexplained. This study aimed to investigate the effect of Brazilian green propolis on cognitive impairment using a mouse model of Alzheimer's disease (AD) induced by intracerebroventricular injection of amyloid beta (Aβ)_25‒35.

Methods

Five-week-old male Slc:ddY mice were randomly divided into five groups (n = 8). The groups were pretreated with vehicle and propolis at a dose of 100, 300 and 900

SUBMITTER: Ito T 

PROVIDER: S-EPMC10656927 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature