Velocity of conduction between columns and layers in barrel cortex reported by parvalbumin interneurons.

ABSTRACT: Inhibitory interneurons expressing parvalbumin (PV) play critical roles throughout the brain. Their rapid spiking enables them to control circuit dynamics on a millisecond time scale, and the timing of their activation by different excitatory pathways is critical to these functions. We used a genetically encoded hybrid voltage sensor to image PV interneuron voltage changes with sub-millisecond precision in primary somatosensory barrel cortex (BC) of adult mice. Electrical stimulation evoked depolarizations with a latency that increased with distance from the stimulating electrode, allowing us to determine conduction velocity. Spread of responses between cortical layers yielded an interlaminar conduction velocity and spread within layers yielded intralaminar conduction velocities in differe

SUBMITTER: Scheuer KS 

PROVIDER: S-EPMC10656945 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature