Intricate role of intestinal microbe and metabolite in schizophrenia.

ABSTRACT:

Background

The brain-gut axis has gained increasing attention due to its contribution to the etiology of various central nervous system disorders. This study aims to elucidate the hypothesis that schizophrenia is associated with disturbances in intestinal microflora and imbalance in intestinal metabolites. By exploring the intricate relationship between the gut and the brain, with the goal of offering fresh perspectives and valuable insights into the potential contribution of intestinal microbial and metabolites dysbiosis to the etiology of schizophrenia.

Methods

In this study, we used a 16S ribosomal RNA (16S rRNA) gene sequence-based approach and an untargeted liquid chromatography-mass spectrometry-based metabolic profiling approach to measure the gut microbiome and micro

SUBMITTER: Shi L 

PROVIDER: S-EPMC10657011 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature