Different equations for estimating age-related changes of glomerular filtration rate in the healthy population.

ABSTRACT: Identifying age-related trend of estimated glomerular filtration rate (eGFR) is necessary to assess whether kidney function is healthily aging. This study aimed to investigate the application of CKD-EPI, FAS, and Xiangya equations for the aging estimation of eGFR in the healthy Chinese individuals. A total of 36,911 healthy individuals were enrolled in this study. We grouped every ten years to observe the trend of eGFR with aging and investigated decline rate of it by general linear regression analysis in each age-groups. Agreement between equations was determined by intraclass correlation coefficient (ICC) and Bland-Altman plot. We calculated reference interval in each age-group. We further analyzed above statistical indicators in males and females. The eGFR by CKD-EPI, and Xiangya equati

SUBMITTER: Wei L 

PROVIDER: S-EPMC10657123 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature