Investigating the prognostic and predictive value of the type II cystatin genes in gastric cancer.

ABSTRACT:

Background

Accumulating evidence indicates that type II cystatin (CST) genes play a pivotal role in several tumor pathological processes, thereby affecting all stages of tumorigenesis and tumor development. However, the prognostic and predictive value of type II CST genes in GC has not yet been investigated.

Methods

The present study evaluated the expression and prognostic value of type II CST genes in GC by using The Cancer Genome Atlas (TCGA) database and the Kaplan-Meier plotter (KM plotter) online database. The type II CST genes related to the prognosis of GC were then screened out. We then validated the expression and prognostic value of these genes by immunohistochemistry. We also used Database for Annotation, Visualization, and Integrated Discovery (DAVID), Gene Multi

SUBMITTER: Chen YY 

PROVIDER: S-EPMC10657128 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature