Ly6C-high monocytes alleviate brain injury in experimental subarachnoid hemorrhage in mice.

ABSTRACT:

Background

Subarachnoid hemorrhage (SAH) is an uncommon type of potentially fatal stroke. The pathophysiological mechanisms of brain injury remain unclear, which hinders the development of drugs for SAH. We aimed to investigate the pathophysiological mechanisms of SAH and to elucidate the cellular and molecular biological response to SAH-induced injury.

Methods

A cross-species (human and mouse) multiomics approach combining high-throughput data and bioinformatic analysis was used to explore the key pathophysiological processes and cells involved in SAH-induced brain injury. Patient data were collected from the hospital (n = 712). SAH was established in adult male mice via endovascular perforation, and flow cytometry, a bone marrow chimera model, qPCR, and microglial depletio

SUBMITTER: Chen H 

PROVIDER: S-EPMC10657171 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature