Personalized prognostic prediction tool for high-grade neuroendocrine cervical cancer: a SEER database analysis and single-center validation.

ABSTRACT:

Purpose

Cervical high-grade neuroendocrine carcinoma (CHGNEC) is a rare but highly aggressive cancer. The purpose of this study is to develop a prognostic nomogram that can accurately predict the outcomes for CHGNEC patients.

Methods

We analyzed clinical data from the Surveillance, Epidemiology, and End Results (SEER) database of CHGNEC patients, including small-cell neuroendocrine carcinoma (SCNEC) and large-cell neuroendocrine carcinoma (LCNEC). We investigated patient characteristics and prognosis, and developed a prognostic nomogram model for cancer-specific survival in CHGNEC patients. External validation was conducted using real clinical cases from our hospital.

Results

Our study included 306 patients from SEER database, with a mean age of 49.9 ± 15.5 years. Mos

SUBMITTER: Chen X 

PROVIDER: S-EPMC10657306 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature