Systemic inflammatory biomarkers as prognostic tools in patients with gastroesophageal adenocarcinoma.

ABSTRACT:

Purpose

Gastroesophageal adenocarcinoma is associated with poor prognosis, even in resectable stages. Systemic inflammation plays a key role in cancer progression. Yet, information on prognostic values of systemic inflammatory parameters in European cohorts is scarce.

Methods

We analysed systemic inflammatory biomarkers (neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation response index (SIRI) and modified Glasgow Prognostic Score (mGPS)) at the time of cancer diagnosis and their association with overall survival (OS) in patients with gastroesophageal adenocarcinoma treated at the Medical University of Vienna between 1990 and 2020.

Results

In this analysis of 769 patients with gastroesoph

SUBMITTER: Puhr HC 

PROVIDER: S-EPMC10657318 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature