Acute and Repeated Ozone Exposures Differentially Affect Circadian Clock Gene Expression in Mice.

ABSTRACT: Circadian rhythms have an established role in regulating physiological processes, such as inflammation, immunity, and metabolism. Ozone, a common environmental pollutant with strong oxidative potential, is implicated in lung inflammation/injury in asthmatics. However, whether O₃ exposure affects the expression of circadian clock genes in the lungs is not known. In this study, changes in the expression of core clock genes are analyzed in the lungs of adult female and male mice exposed to filtered air (FA) or O₃ using qRT-PCR. The findings are confirmed using an existing RNA-sequencing dataset from repeated FA- and O₃ -exposed mouse lungs and validated by qRT-PCR. Acute O₃ exposure significantly alters the expression of clock genes in the lungs of

SUBMITTER: Sundar IK 

PROVIDER: S-EPMC10657336 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature