Metaproteogenomic analysis of saliva samples from Parkinson's disease patients with cognitive impairment.

ABSTRACT: Cognitive impairment (CI) is very common in patients with Parkinson's Disease (PD) and progressively develops on a spectrum from mild cognitive impairment (PD-MCI) to full dementia (PDD). Identification of PD patients at risk of developing cognitive decline, therefore, is unmet need in the clinic to manage the disease. Previous studies reported that oral microbiota of PD patients was altered even at early stages and poor oral hygiene is associated with dementia. However, data from single modalities are often unable to explain complex chronic diseases in the brain and cannot reliably predict the risk of disease progression. Here, we performed integrative metaproteogenomic characterization of salivary microbiota and tested the hypothesis that biological molecules of saliva and saliva microbi

SUBMITTER: Arıkan M 

PROVIDER: S-EPMC10657361 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature