The role of specific isoforms of Ca_V2 and the common C-terminal of Ca_V2 in calcium channel function in sensory neurons of Aplysia.

ABSTRACT: The presynaptic release apparatus can be specialized to enable specific synaptic functions. Habituation is the diminishing of a physiological response to a frequently repeated stimulus and in Aplysia, habituation to touch is mediated by a decrease in transmitter release from the sensory neurons that respond to touch even after modest rates of action potential firing. This synaptic depression is not common among Aplysia synaptic connections suggesting the presence of a release apparatus specialized for this depression. We found that specific splice forms of ApCa_V2, the calcium channel required for transmitter release, are preferentially used in sensory neurons, consistent with a specialized release apparatus. However, we were not able to find a specific ApCa_V2 splice u

SUBMITTER: Dunn TW 

PROVIDER: S-EPMC10657410 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature