Explainable deep learning for tumor dynamic modeling and overall survival prediction using Neural-ODE.

ABSTRACT: While tumor dynamic modeling has been widely applied to support the development of oncology drugs, there remains a need to increase predictivity, enable personalized therapy, and improve decision-making. We propose the use of Tumor Dynamic Neural-ODE (TDNODE) as a pharmacology-informed neural network to enable model discovery from longitudinal tumor size data. We show that TDNODE overcomes a key limitation of existing models in its ability to make unbiased predictions from truncated data. The encoder-decoder architecture is designed to express an underlying dynamical law that possesses the fundamental property of generalized homogeneity with respect to time. Thus, the modeling formalism enables the encoder output to be interpreted as kinetic rate metrics, with inverse time as the physical

SUBMITTER: Laurie M 

PROVIDER: S-EPMC10657412 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature