Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure.

ABSTRACT: Patients exposed to trauma often experience high rates of adverse post-traumatic neuropsychiatric sequelae (APNS). The biological mechanisms promoting APNS are currently unknown, but the microbiota-gut-brain axis offers an avenue to understanding mechanisms as well as possibilities for intervention. Microbiome composition after trauma exposure has been poorly examined regarding neuropsychiatric outcomes. We aimed to determine whether the gut microbiomes of trauma-exposed emergency department patients who develop APNS have dysfunctional gut microbiome profiles and discover potential associated mechanisms. We performed metagenomic analysis on stool samples (n = 51) from a subset of adults enrolled in the Advancing Understanding of RecOvery afteR traumA (AURORA) study. Two-, eight- and twelve

SUBMITTER: Zeamer AL 

PROVIDER: S-EPMC10657470 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature