Protective effects of ginsenosides in cisplatin-induced kidney injury: A systematic review, meta-analysis.

ABSTRACT: Although evidence suggests ginsenosides, the primary active and distinctive components of ginseng, have beneficial effects in cisplatin-induced nephrotoxicity, their efficacy and protective mechanisms remain unclear. The aim of the current meta-analysis is to study the effectiveness and mechanisms of ginsenosides in a model of nephrotoxicity induced by cisplatin. Preclinical investigations were conducted in the search of various databases including Medline, Web of Science, Google, CNKI, Embase, and the Wanfang database. 12 studies with 216 animals were included in this review. Stata 15.0 and RevMan 5.3 were used for statistical analyses. The pooled results showed that ginsenosides significantly improved kidney function, and inhibited histological damage. The protective mechanism of ginseno

SUBMITTER: Luo X 

PROVIDER: S-EPMC10657623 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature