Cerebral Small Vessel Disease Is Associated with Motor, Cognitive, and Emotional Dysfunction in Multiple System Atrophy.

ABSTRACT:

Background

Cerebral small vessel disease (CSVD) has not been systematically studied in patients with multiple system atrophy (MSA).

Objective

We sought to explore whether MSA patients suffer from a heavier CSVD burden relative to healthy individuals and whether CSVD has a relationship with motor, cognitive, and emotional dysfunction in patients with MSA.

Methods

This study consecutively recruited 190 MSA patients and 190 matched healthy controls whose overall CSVD burden and single CSVD imaging markers (including white matter hyperintensity (WMH), microbleeds, lacunes, and enlarged perivascular spaces (EPVS)) were measured. Of the MSA patients, 118 completed multi-dimensional outcome assessments. Spearman's correlations and multivariable linear regressions were perfor

SUBMITTER: Yang XL 

PROVIDER: S-EPMC10657662 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature