Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease.
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ABSTRACT:
SUBMITTER: Ukraintseva S
PROVIDER: S-EPMC10657669 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease.
Ukraintseva Svetlana S Duan Matt M Simanek Amanda M AM Holmes Rachel R Bagley Olivia O Rajendrakumar Aravind L AL Yashkin Arseniy P AP Akushevich Igor I Tropsha Alexander A Whitson Heather H Yashin Anatoliy A Arbeev Konstantin K
Journal of Alzheimer's disease : JAD 20230101 2
Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer's disease (AD). In this retrospective cohort study, we used Cardiovascular Health Study data to estimate associations of pneumococcal polysaccharide vaccine and flu shots received between ages 65-75 with AD onset at age 75 or older, taking into account rs6859 polymorphism in NECTIN2 gene (AD risk factor). Pneumococcal vaccine, and total count of vaccinations against pneumonia and flu, were associa ...[more]
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