Longitudinal Changes in Neuropsychological Functioning in Japanese Patients with Myotonic Dystrophy Type 1: A Five Year Follow-Up Study.

ABSTRACT:

Background

Myotonic dystrophy type 1 (DM1) is a form of muscular dystrophy that causes various symptoms, including those of the central nervous system. Some studies have reported cognitive decline in patients with DM1, although the available evidence is limited.

Objective

This study aimed to describe longitudinal differences in neuropsychological function in patients with DM1.

Methods

A total of 66 Japanese adult patients with DM1 were investigated using a neuropsychological battery to assess several cognitive domains, including memory, processing speed, and executive function. The patients underwent neuropsychological evaluation approximately five years after baseline (Times 1 and 2).

Results

Thirty-eight patients underwent a second neuropsychological evaluati

SUBMITTER: Fujino H 

PROVIDER: S-EPMC10657671 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature