Towards the Identification of Biomarkers for Muscle Function Improvement in Myotonic Dystrophy Type 1.

ABSTRACT:

Background

Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults. In DM1 patients, skeletal muscle is severely impaired, even atrophied and patients experience a progressive decrease in maximum strength. Strength training for these individuals can improve their muscle function and mass, however, the biological processes involved in these improvements remain unknown.

Objective

This exploratory study aims at identifying the proteomic biomarkers and variables associated with the muscle proteome changes induced by training in DM1 individuals.

Methods

An ion library was developed from liquid chromatography-tandem mass spectrometry proteomic analyses of Vastus Lateralis muscle biopsies collected in 11 individuals with DM1 pre-and post-training.

SUBMITTER: Aoussim A 

PROVIDER: S-EPMC10657677 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature