Reconceptualization of the Erlangen Score for the Assessment of Dementia Risk: The ERlangen Score.

ABSTRACT:

Background

The established Erlangen Score (ES) for the interpretation of cerebrospinal fluid (CSF) biomarkers in the diagnostics of Alzheimer's disease (AD) uses markers of amyloidopathy and tauopathy, equally weighted to form an easy-interpretable ordinal scale. However, these biomarkers are not equally predictive for AD.

Objective

The higher weighting of the Aβ42/Aβ40 ratio, as a reconceptualized ERlangen Score (ERS), was tested for advantages in diagnostic performance.

Methods

Non-demented subjects (N = 154) with a mean follow up of 5 years were assigned to a group ranging from 0 to 4 in ES or ERS. Psychometric trajectories and dementia risk were assessed.

Results

The distribution of subjects between ES and ERS among the groups differed considerably, as grou

SUBMITTER: Utz J 

PROVIDER: S-EPMC10657695 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature