Carbonic anhydrase inhibitors limit complications in X-linked retinoschisis.

ABSTRACT:

Purpose

Carbonic anhydrase inhibitors (CAIs) reduce macular schisis in patients with X-linked retinoschisis (XLRS). The purpose of this study was to determine if CAIs reduce the incidence of complications from XLRS, including macular atrophy, retinal tears, and retinal detachment (RD), the most common causes of vision loss in patients with XLRS.

Methods

For this retrospective interventional case series, a chart review of patients examined at Cincinnati Children's Hospital Medical Center [CCHMC] and Cincinnati Eye Institute [CEI] between 1/1/2015 and 1/16/2023 was performed. Male patients were included based on genetically-confirmed RS1 or typical clinical presentation with known family history of XLRS with at least two follow-up visits.

Results

Twenty-eight pat

SUBMITTER: Wey S 

PROVIDER: S-EPMC10657813 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature