Brain plasticity following corpus callosum agenesis or loss: a review of the Probst bundles.

ABSTRACT: The corpus callosum is the largest axonal tract in the human brain, connecting the left and right cortical hemipheres. This structure is affected in myriad human neurodevelopmental disorders, and can be entirely absent as a result of congenital or surgical causes. The age when callosal loss occurs, for example via surgical section in cases of refractory epilepsy, correlates with resulting brain morphology and neuropsychological outcomes, whereby an earlier loss generally produces relatively improved interhemispheric connectivity compared to a loss in adulthood (known as the "Sperry's paradox"). However, the mechanisms behind these age-dependent differences remain unclear. Perhaps the best documented and most striking of the plastic changes that occur due to developmental, but not adult, ca

SUBMITTER: Lynton Z 

PROVIDER: S-EPMC10657877 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature