Radiomic analysis will add differential diagnostic value of benign and malignant pulmonary nodules: a hybrid imaging study based on [¹⁸F]FDG and [¹⁸F]FLT PET/CT.

ABSTRACT:

Purpose

To investigate the clinical value of radiomic analysis on [¹⁸F]FDG and [¹⁸F]FLT PET on the differentiation of [¹⁸F]FDG-avid benign and malignant pulmonary nodules (PNs).

Methods

Data of 113 patients with inconclusive PNs based on preoperative [¹⁸F]FDG PET/CT who underwent additional [¹⁸F]FLT PET/CT scans within a week were retrospectively analyzed in the present study. Three methods of analysis including visual analysis, radiomic analysis based on [¹⁸F]FDG PET/CT images alone, and radiomic analysis based on dual-tracer PET/CT images were evaluated for differential diagnostic value of benign and malignant PNs.

Results

A total of 678 radiomic features were extracted from volumes of interest (VOIs)

SUBMITTER: Ning J 

PROVIDER: S-EPMC10657912 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature