Causal relationships between type 2 diabetes, glycemic traits and keratoconus.

ABSTRACT:

Purpose

The relationship between diabetes mellitus and keratoconus remains controversial. This study aimed to assess the potential causal relationships among type 2 diabetes, glycemic traits, and the risk of keratoconus.

Methods

We used a two-sample Mendelian randomization (MR) design based on genome-wide association summary statistics. Fasting glucose, proinsulin levels, adiponectin, hemoglobin A1c (HbA1c) and type 2 diabetes with and without body mass index (BMI) adjustment were used as exposures and keratoconus was used as the outcome. MR analysis was performed using the inverse-variance weighted method, MR-Egger regression method, weighted-mode method, weighted median method and the MR-pleiotropy residual sum and outlier test (PRESSO).

Results

Results showed that

SUBMITTER: Zhu X 

PROVIDER: S-EPMC10658005 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature