Proteomic association with age-dependent sex differences in Wisconsin Card Sorting Test performance in healthy Thai subjects.

ABSTRACT: Sex differences in cognitive function exist, but they are not stable and undergo dynamic change during the lifespan. However, our understanding of how sex-related neural information transmission evolves with age is still in its infancy. This study utilized the Wisconsin Card Sorting Test (WCST) and the label-free proteomics method with bioinformatic analysis to investigate the molecular mechanisms underlying age-related sex differences in cognitive performance in 199 healthy Thai subjects (aged 20-70 years), as well as explore the sex-dependent protein complexes for predicting cognitive aging. The results showed that males outperformed females in two of the five WCST sub-scores: %Corrects and %Errors. Sex differences in these scores were related to aging, becoming noticeable in those over

SUBMITTER: Chen C 

PROVIDER: S-EPMC10658079 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature