N6-methyladenosine of TRIM27 enhances the stem cell-type phenotype of cisplatin-resistant colorectal cancer cells.

ABSTRACT: Colorectal cancer (CRC), classified as a lethal form of cancer, substantially threatens human well-being. Cancer stem cells (CSCs) reflect subsets for cancerous cells having basic stem-cell type properties, being significantly involved in the development of chemoresistance and tumor relapsing. The aberrant TRIM27 expression in various types of cancer indicates its potential involvement in cancer growth and progression. The current understanding of the TRIM27 involvement in CRC remains limited. In current study indicated that TRIM27 can potentially promote CSC-type phenotype of Cisplatin (DDP)-resistant CRC cells. YTHDF1 recruitment onto m⁶A-amended TRIM27 was crucial for facilitating the TRIM27 translating process in DDP-resistant CRC ce

SUBMITTER: Zheng JQ 

PROVIDER: S-EPMC10658205 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature