Alkali-treated titanium dioxide promotes formation of proteoglycan layer and altered calcification and immunotolerance capacity in bone marrow stem cell.

ABSTRACT:

Introduction

In this study, we report that a proteoglycans (PGs)-layer between the bone and titanium dioxide (TiO₂) surface after osseointegration improved the calcification capacity and immunotolerance of human bone marrow mesenchymal stem cells (hBMSCs) on TiO₂. Alkaline treatment of TiO₂ is a method for promoting osteogenesis in hBMSCs. We hypothesized that promotion of osteogenesis due to alkaline treatment was caused by changing PGs-layer on TiO₂.

Objective

This study aimed to analyze whether alkaline treatment of TiO₂ affects PGs-layer formation and immunotolerance in hBMSCs.

Methods

The topology and wettability of the alkaline-treated titanium (Ti-Al) and unprocessed titanium (Ti-MS) surfaces were character

SUBMITTER: Mizutani T 

PROVIDER: S-EPMC10658208 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature