Clinical and Histopathologic Characteristics of Pediatric Patients With Primary Membranous Nephropathy.

ABSTRACT:

Introduction

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected children are scarce. In recent years, several novel antigens have been implicated in the pathogenesis of PMN. However, the histopathologic characteristics of pediatric patients with PMN remain poorly represented in the literature.

Methods

We have retrospectively analyzed the clinical presentation and outcomes data of 21 children with PMN from 3 centers in the United States. In addition, we have identified novel antigens in biopsy specimens from these patients and correlated their presence or absence to clinical outcomes. Finally, we compared the results of the novel antigen staining from our clinical cohort to a validation cohort of 127 biopsy specime

SUBMITTER: Kouri AM 

PROVIDER: S-EPMC10658230 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature