Focal Segmental Glomerulosclerosis: Assessing the Risk of Relapse.

ABSTRACT:

Introduction

Kidney outcomes are improved in primary focal segmental glomerulosclerosis (FSGS) by maintaining a remission in proteinuria. However, characteristics associated with relapses are uncertain. We sought to identify these by analyzing each remission.

Methods

We performed a retrospective study in patients with biopsy-proven lesions of FSGS, absent identifiable secondary cause, who had at least 1 remission from nephrotic-range proteinuria. In each patient, we identified every remission, every relapse, and their durations. Using a multilevel logistic regression to account for the clustering of multiple remissions within a patient, we tested which clinical characteristics were independently associated with relapses.

Results

In 203 individuals, 312 remissions occu

SUBMITTER: Troyanov S 

PROVIDER: S-EPMC10658237 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature