Advantages and disadvantages of treatment of experimental ARDS by M2-polarized RAW 264.7 macrophages.

ABSTRACT: Innate immunity reactions are core to any immunological process, including systemic inflammation and such extremes as acute respiratory distress syndrome (ARDS) and cytokine storm. Macrophages, the key cells of innate immunity, show high phenotypic plasticity: depending on microenvironmental cues, they can polarize into M1 (classically activated, pro-inflammatory) or M2 (alternatively activated, anti-inflammatory). The anti-inflammatory M2 macrophage polarization-based cell therapies constitute a novel prospective modality. Systemic administration of 'educated' macrophages is intended at their homing in lungs in order to mitigate the pro-inflammatory cytokine production and reduce the risks of 'cytokine storm' and related severe complications. Acute respiratory distress syndrome (ARDS) is

SUBMITTER: Kosyreva AM 

PROVIDER: S-EPMC10658332 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature