Antimalarial activity of Toona ciliata MJ Roem aqueous methanolic leaf extract and its antioxidant and phytochemical properties.

ABSTRACT:

Background and aim

Malaria is a global health issue causing substantial morbidity and mortality. Screening of various traditionally important medicinal plants is a key source for the discovery of new antimalarials. We evaluated the antimalarial and antioxidant activities, and performed detailed phytochemical analyses of Toona ciliata MJ Roem aqueous methanolic leaf extract (TcMLE).

Experimental procedures

In vitro antiplasmodial studies in Plasmodium falciparum (Pf) 3D7 and PfCam3.I^R539T strains were performed by [³H]-hypoxanthine uptake assays. In vitro cytotoxicity in HeLa and HEK293T cell lines was evaluated using MTT assays. Hemolysis assay was performed using RBCs. Phytochemical analysis by GC-MS and

SUBMITTER: Singh N 

PROVIDER: S-EPMC10658347 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature