Risk of Urological Cancer Among Boys and Men Born with Hypospadias: A Swedish Population-based Study.

ABSTRACT:

Background

Hypospadias is a common genital malformation among boys. Studies indicate that hypospadias is associated with a higher risk of testicular cancer. Other forms of urological cancer may be linked to hypospadias via a mutual aetiology, hormonal dysfunction, or hypospadias complications, but this has not yet been studied.

Objective

To investigate the association between hypospadias and testicular cancer and the risk of other urological cancers among individuals born with hypospadias.

Design setting and participants

The study used a population-based male cohort born in Sweden in 1964-2018. Exposure was hypospadias diagnosis in national registers. Outcomes were defined using the Swedish Cancer Register. An extended cohort born from 1940 was used to study cancers a

SUBMITTER: Phillips L 

PROVIDER: S-EPMC10658418 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature