Increased plasma DR-70 (fibrinogen-fibrin degradation products) concentrations as a diagnostic biomarker in dogs with neoplasms.

ABSTRACT:

Background

Tumor biomarkers have used widely in clinical oncology in human medicine. Only a few studies have evaluated the clinical utility of tumor biomarkers for veterinary medicine. A test for fibrinogen and fibrin degradation products (DR-70) has been proposed as an ideal biomarker for tumors in humans. The clinical value of DR-70 for veterinary medicine however has yet to be determined.

Objectives

Investigate the diagnostic value of DR-70 concentrations by comparing them between healthy dogs and dogs with tumors.

Animals

Two hundred sixty-three dogs with different types of tumors were included. Sixty healthy dogs also were recruited for comparison.

Methods

The DR-70 concentrations were measured in all recruited individuals by ELISA. Clinical conditions wer

SUBMITTER: Ke CH 

PROVIDER: S-EPMC10658483 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature